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Variability of 5-HT2C receptor cys23ser polymorphism among European populations and vulnerability to affective disorder

✍ Scribed by Lerer, B; Macciardi, F; Segman, R H; Adolfsson, R; Blackwood, D; Blairy, S; Del Favero, J; Dikeos, D G; Kaneva, R; Lilli, R

Book ID: 110059333
Publisher: Nature Publishing Group
Year: 2001
Tongue: English
Weight: 141 KB
Volume: 6
Category: Article
ISSN: 1359-4184
DOI: 10.1038/sj.mp.4000883

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Transgenic mice lacking a functional 5-HT 2c receptor gene are extremely susceptible to audiogenic seizures, suggesting that 5-HT 2c receptors mediate inhibition of neuronal network excitability. The present association study tested the hypothesis that a Cys23Ser substitution polymorphism within the