✦ LIBER ✦

Pharmacological characterization of Lu 25-109-T, a compound with M1 agonistic and M2M3-antagonistic effects on muscarinic receptors

✍ Scribed by E. Meier; J. Arnt; K. Frederiksen; H.L. Lembøl; C. Sánchez; T. Skarsfeldt; N. Dragsted; H. Pedersen; J. Hyttel

Book ID: 118347464
Publisher: Elsevier Science
Year: 1995
Tongue: English
Weight: 112 KB
Volume: 56
Category: Article
ISSN: 0024-3205
DOI: 10.1016/0024-3205(95)93724-s

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Pharmacological in vitro characterizatio

Pharmacological in vitro characterization of the arecoline bioisostere, Lu 25-109-T, a muscarinic compound with M1-agonistic and M2/M3-antagonistic properties

✍ Eddi Meier; Kristen Frederiksen; Mogens Nielsen; Hanne Løve Lembøl; Henrik Peder 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 210 KB 👁 1 views

The arecoline bioisostere, Lu 25-109-T, displays a pharmacological profile of a partial muscarinic agonist with a several-fold higher affinity for cortical M 1 receptors than for brain stem M 2 receptors and salivary glands M 3 receptors. The compound is selective for muscarinic receptors as it show

In vivo muscarinic cholinergic mediated

In vivo muscarinic cholinergic mediated effects of Lu 25-109, a M1 agonist and M2/M3 antagonist in vitro

✍ C. Sánchez; Jørn Arnt; Michael Didriksen; N. Dragsted; Sibylle Moltzen Lenz; Jør 📂 Article 📅 1998 🏛 Springer 🌐 English ⚖ 116 KB

Characterization of functional effects o

Characterization of functional effects of Z-338, a novel gastroprokinetic agent, on the muscarinic M1, M2, and M3 receptors expressed in Xenopus oocytes

✍ Y. Doi; O. Murasaki; M. Kaibara; Y. Uezono; H. Hayashi; K. Yano; K. Taniyama 📂 Article 📅 2004 🏛 Elsevier Science 🌐 English ⚖ 275 KB

Affinities of muscarinic drugs for [3H]N

Affinities of muscarinic drugs for [3H]N-methylscopolamine (NMS) and [3H]oxotremorine (OXO) binding to a mixture of M1−M4muscarinic receptors: Use of NMS/OXO-M ratios to group compounds into potential agonist, partial agonist, and antagonist classes

✍ N. A. Sharif; G. W. Williams; L. M. DeSantis 📂 Article 📅 1995 🏛 Springer 🌐 English ⚖ 549 KB

ChemInform Abstract: Synthesis and Struc

ChemInform Abstract: Synthesis and Structure-Activity Studies of a Series of 1-Oxa-2,8- diazaspiro(4.5)decan-3-ones and Related Compounds as M1 Muscarinic Agonists.

✍ S. TSUKAMOTO; H. NAGAOKA; S. IGARASHI; F. WANIBUCHI; K. HIDAKA; T. TAMURA 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 37 KB

ChemInform Abstract: Synthesis of Novel

ChemInform Abstract: Synthesis of Novel Succinamide Derivatives Having a 5,11-Dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one Skeleton as Potent and Selective M2 Muscarinic Receptor Antagonists. Part 2.

✍ T. WATANABE; A. KAKEFUDA; I. KINOYAMA; K. TAKIZAWA; S. HIRANO; H. SHIBATA; I. YA 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 36 KB 👁 2 views

Synthesis of Novel Succinamide Derivatives Having a 5,11-Dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one Skeleton as Potent and Selective M 2 Muscarinic Receptor Antagonists. Part 2. -Among the screened compounds derivative (IIIe) exhibits the highest affinity for M 2 muscarinic receptors and (III