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In vivo muscarinic cholinergic mediated effects of Lu 25-109, a M1 agonist and M2/M3 antagonist in vitro

✍ Scribed by C. Sánchez; Jørn Arnt; Michael Didriksen; N. Dragsted; Sibylle Moltzen Lenz; Jørgen Matz

Book ID
105884585
Publisher
Springer
Year
1998
Tongue
English
Weight
116 KB
Volume
137
Category
Article
ISSN
0033-3158

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Pharmacological in vitro characterizatio
Pharmacological in vitro characterization of the arecoline bioisostere, Lu 25-109-T, a muscarinic compound with M1-agonistic and M2/M3-antagonistic properties
✍ Eddi Meier; Kristen Frederiksen; Mogens Nielsen; Hanne Løve Lembøl; Henrik Peder 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 210 KB 👁 1 views

The arecoline bioisostere, Lu 25-109-T, displays a pharmacological profile of a partial muscarinic agonist with a several-fold higher affinity for cortical M 1 receptors than for brain stem M 2 receptors and salivary glands M 3 receptors. The compound is selective for muscarinic receptors as it show