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In vivo and in vitro pharmacological characterization of SVT-40776, a novel M3 muscarinic receptor antagonist, for the treatment of overactive bladder

✍ Scribed by C Salcedo; S Davalillo; J Cabellos; C Lagunas; D Balsa; S Pérez-del-Pulgar; M Ballarín; AG Fernández


Book ID
111218114
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
449 KB
Volume
156
Category
Article
ISSN
0007-1188

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Pharmacological in vitro characterizatio
✍ Eddi Meier; Kristen Frederiksen; Mogens Nielsen; Hanne Løve Lembøl; Henrik Peder 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 210 KB 👁 1 views

The arecoline bioisostere, Lu 25-109-T, displays a pharmacological profile of a partial muscarinic agonist with a several-fold higher affinity for cortical M 1 receptors than for brain stem M 2 receptors and salivary glands M 3 receptors. The compound is selective for muscarinic receptors as it show