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Pharmacokinetics of trimethoprim/sulfadiazine in neonatal calves: influence of synovitis

โœ Scribed by S. E. SHOAF; W. S. SCHWARK; C. L. GUARD; R. V. SCHWARTSMAN

Book ID
114744431
Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
503 KB
Volume
9
Category
Article
ISSN
0140-7783

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Pharmacokinetics of aditoprim and trimet
Pharmacokinetics of aditoprim and trimethoprim in buffalo calves
โœ M. Perwaiz Iqbal; M. Khalid Ashfaq; Sarfaraz K. Niazi; M. Mahboobali; Khalid N. ๐Ÿ“‚ Article ๐Ÿ“… 1994 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 250 KB ๐Ÿ‘ 1 views

Pharmacokinetic parameters of two antifolates, trimethoprim and aditoprim, were studied in buffalo calves. The elimination half-life of aditoprim (6-14 h) was nearly twice as long as that of trimethoprim (3.08h) and compares well with values observed in heifers. This longer half-life of aditoprim is