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Pharmacokinetics of aditoprim and trimethoprim in buffalo calves

โœ Scribed by M. Perwaiz Iqbal; M. Khalid Ashfaq; Sarfaraz K. Niazi; M. Mahboobali; Khalid N. Khawaja

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
250 KB
Volume
15
Category
Article
ISSN
0142-2782

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โœฆ Synopsis

Pharmacokinetic parameters of two antifolates, trimethoprim and aditoprim, were studied in buffalo calves. The elimination half-life of aditoprim (6-14 h) was nearly twice as long as that of trimethoprim (3.08h) and compares well with values observed in heifers. This longer half-life of aditoprim is a result of its much larger distribution volume (four to five times larger) because the clearance of aditoprim was about twice as high as that of trimethoprim. The longer half-life of aditoprim is expected to give a longer duration of in vivo bacteriostatic activity than that of trimethoprim.

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