Pharmacokinetics of the selective benzodiazepine antagonist Ro 15-1788 in man
β Scribed by U. Klotz; G. Ziegler; I. W. Reimann
- Publisher
- Springer
- Year
- 1984
- Tongue
- English
- Weight
- 289 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0031-6970
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π SIMILAR VOLUMES
The metabolic fate of the benzodiazepine antagonist RO 15-1788 labelled with "C was studied in plasma from human subjects after intravenous administration in connection with positron emission tomography. R o 15-1788 and its metabolites were separated by thin-layer chromatography and the radioactivit
Ro 15-1788, a benzodiazepine antagonist, has been advocated as a new treatment for hepatic encephalopathy. This drug is extensively metabolized by the liver in normal subjects. In the present study, we examined Ro 15-1 788 disposition in eight healthy controls (Group I), eight cirrhotic patients wit