✦ LIBER ✦
Metabolism of the benzodiazepine antagonist 11C-Ro 15-1788 after intravenous administration in man
✍ Scribed by Carl-Gunnar Swahn; Anders Persson; Stefan Pauli
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 359 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0885-6222
No coin nor oath required. For personal study only.
✦ Synopsis
The metabolic fate of the benzodiazepine antagonist RO 15-1788 labelled with "C was studied in plasma from human subjects after intravenous administration in connection with positron emission tomography. R o 15-1788 and its metabolites were separated by thin-layer chromatography and the radioactivity in the different compounds was determined. "C-Ro 15-1788 was extensively and rapidly metabolised to the corresponding free acid. At 36 minutes after administration only 50% of the radioactivity in plasma represented unchanged compound.