The effects of the benzodiazepine (BZD) receptor antagonist RO 15-1788 (3 mg/kg) on the anxiolytic properties of ethanol in mice confronted with a light/dark choice procedure and with the staircase test were investigated. RO 15-1788 reversed the effects of ethanol on some of the behavioural paramete
Amnestic effects of lormetazepam and their reversal by the benzodiazepine antagonist Ro 15-1788
β Scribed by R. Dorow; D. Berenberg; T. Duka; N. Sauerbrey
- Publisher
- Springer
- Year
- 1987
- Tongue
- English
- Weight
- 889 KB
- Volume
- 93
- Category
- Article
- ISSN
- 0033-3158
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The metabolic fate of the benzodiazepine antagonist RO 15-1788 labelled with "C was studied in plasma from human subjects after intravenous administration in connection with positron emission tomography. R o 15-1788 and its metabolites were separated by thin-layer chromatography and the radioactivit
Noradrenaline (NA) plasma levels were examined in 18 healthy volunteers on 2 consecutive days after a single treatment with either lormetazepam (0.06 mg/kg) (LMZ group), flunitrazepam (0.03 mg/kg) (FNZ group) or placebo (PLA group) in combination with the benzodiazepine (BZ) antagonist Ro 15-1788 (0