11C-labelling of the benzodiazepine antagonist RO 15–1788, in two different positions, and its main metabolite RO 15–3890
✍ Scribed by C. Halldin; S. Stone-Elander; J-O. Thorell; A. Persson; G. Sedvall
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- French
- Weight
- 112 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0022-2135
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📜 SIMILAR VOLUMES
The metabolic fate of the benzodiazepine antagonist RO 15-1788 labelled with "C was studied in plasma from human subjects after intravenous administration in connection with positron emission tomography. R o 15-1788 and its metabolites were separated by thin-layer chromatography and the radioactivit
The determination of the percentage of unchanged [11C]Ro 15-1788 with respect to total radioactivity, essential for the pharmacokinetic exploitation of data of blood radioactivity decrease obtained in PET studies, may be carried out with equal results using either an extraction procedure or a TLC me