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Pharmacokinetics of TDP223206 following intravenous and oral administration to intact rats and intravenous administration to bile duct-cannulated rats

✍ Scribed by Yanmin Chen; Deping Cheng; Juan Jose Marugan; Carl Manthey; Bruce Tomczuk; Norman Huebert

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
201 KB
Volume
29
Category
Article
ISSN
0142-2782

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The purpose of this study was to characterize CI-992 pharmacokinetics and pharmacokinetics/pharmacodynamics (PK/PD) in sodium deplete monkeys. Panels of monkeys were administered CI-992 as a 1 h intravenous infusions (0.1 and 1 mg kg -1 ) or as single oral doses (0, 10, 50, and 100 mg kg -1 ). Mean