✦ LIBER ✦

Pharmacokinetics of propetamphos following intravenous administration in the F344 rat

✍ Scribed by Dix, Kelly ;Burka, Leo T. ;Dauterman, Walter C.

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 577 KB
Volume: 7
Category: Article
ISSN: 0887-2082
DOI: 10.1002/jbt.2570070402

No coin nor oath required. For personal study only.

✦ Synopsis

ceptibility to propetamphos toxicity. Female rats presented with overt signs of organophosphate intoxication, whereas males were only slightly effected. The observed gender-related clinical difference in susceptibility to toxicity suggests that there may be a difference in the extent of elimination due to activation versus detoxication of propetamphos in males and females. Another possible explanation for the clinical difference in propetamphos toxicity is that inhibition of acetylcholinesterase by the activated, oxygenated form of propetamphos (propetamphos oxon) may be greater in females than in males.

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