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Pharmacokinetics of methotrexate administered by intramuscular and subcutaneous injections in patients with rheumatoid arthritis

✍ Scribed by Paul J. Brooks; William J. Spruill; Roy C. Parish; Daniel A. Birchmore


Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
326 KB
Volume
33
Category
Article
ISSN
0004-3591

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## Abstract ## Objective There is evidence supporting a therapeutic range for methotrexate polyglutamate (MTXGlu) concentrations in the treatment of rheumatoid arthritis (RA). Knowledge of the pharmacokinetics of MTXGlu~1–5~ is required for optimal timing of blood sampling. The aim of this study w