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Pharmacokinetics, safety, and efficacy of combination treatment with methotrexate and leflunomide in patients with active rheumatoid arthritis

✍ Scribed by Michael E. Weinblatt; Joel M. Kremer; Jonathan S. Coblyn; Agnes L. Maier; Simon M. Helfgott; Martin Morrell; Vilma M. Byrne; Mari V. Kaymakcian; Vibeke Strand


Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
134 KB
Volume
42
Category
Article
ISSN
0004-3591

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## Abstract Phenylketonuria (PKU) is an inherited metabolic disease characterized by phenylalanine (Phe) accumulation, which can lead to neurocognitive and neuromotor impairment. Sapropterin dihydrochloride, an FDA‐approved synthetic formulation of tetrahydrobiopterin (6R‐BH4, herein referred to as