Pharmacokinetics of intravenous and oral DA-8159, a new erectogenic, in rats with protein-calorie malnutrition
β Scribed by Hyun J. Shim; Yu C. Kim; Joo H. Lee; Byung O. Ahn; Jong W. Kwon; Won B. Kim; Inchul Lee; Myung G. Lee
- Book ID
- 111769445
- Publisher
- Pharmaceutical Press
- Year
- 2004
- Tongue
- English
- Weight
- 163 KB
- Volume
- 56
- Category
- Article
- ISSN
- 2042-7158
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The purposes of this study were to report dose-independent (after intravenous administration) and dose-dependent (after oral administration) area under the curve of plasma concentration versus time from time zero to time infinity (AUC), and gastric, intestinal, and/or hepatic first-pass effects (aft
## Abstract The changes in pharmacokinetics of DAβ8159 by omeprazole with respect to inhibition of CYP3A1/2 in rats were evaluated. After oral administration of DAβ8159 at dose of 30 mg/kg to rats pretreated with oral omeprazole at 30 mg/kg for 1 week, the total area under the plasma concentrationβ