## Abstract The changes in pharmacokinetics of DAβ8159 by omeprazole with respect to inhibition of CYP3A1/2 in rats were evaluated. After oral administration of DAβ8159 at dose of 30 mg/kg to rats pretreated with oral omeprazole at 30 mg/kg for 1 week, the total area under the plasma concentrationβ
Negligible pharmacokinetic interaction between oral DA-8159, a new erectogenic, and amlodipine in rats
β Scribed by Joo H. Lee; Eun J. Kim; Jong W. Kwon; Moohi Yoo; Myung G. Lee
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 100 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0142-2782
- DOI
- 10.1002/bdd.491
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Time-averaged total body clearance (Cl) and apparent volume of distribution at steady state (V SS ) of DA-8159 after intravenous administration to mice (30 mg/kg), rats (30 mg/kg), rabbits (30 mg/kg) and dogs (3 mg/kg) were analysed as a function of species body weight (W) using the allometric equat
The subacute toxicities and toxicokinetics of a new erectogenic, DA-8159, were evaluated after single (at the 1st day) and 4-week (at the 28th day) oral administration of the drug, in doses of 0 (to serve as a control), 12.5, 50 and 200 mg/kg/day, to male and female dogs (n ΒΌ 3 for male and female d