𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Negligible pharmacokinetic interaction between oral DA-8159, a new erectogenic, and amlodipine in rats

✍ Scribed by Joo H. Lee; Eun J. Kim; Jong W. Kwon; Moohi Yoo; Myung G. Lee


Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
100 KB
Volume
27
Category
Article
ISSN
0142-2782

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Effects of omeprazole or cola beverage o
✍ Joo H. Lee; Soo K. Bae; Jong W. Kwon; Won B. Kim; Myung G. Lee πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 91 KB πŸ‘ 2 views

## Abstract The changes in pharmacokinetics of DA‐8159 by omeprazole with respect to inhibition of CYP3A1/2 in rats were evaluated. After oral administration of DA‐8159 at dose of 30 mg/kg to rats pretreated with oral omeprazole at 30 mg/kg for 1 week, the total area under the plasma concentration–

Interspecies pharmacokinetic scaling of
✍ Hyun J. Shim; Yu C. Kim; Joo H. Lee; Jong W. Kwon; Won B. Kim; Yoon G. Kim; So H πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 122 KB πŸ‘ 2 views

Time-averaged total body clearance (Cl) and apparent volume of distribution at steady state (V SS ) of DA-8159 after intravenous administration to mice (30 mg/kg), rats (30 mg/kg), rabbits (30 mg/kg) and dogs (3 mg/kg) were analysed as a function of species body weight (W) using the allometric equat

Subacute toxicities and toxicokinetics o
✍ Hyun J. Shim; Eun J. Lee; Jung H. Kim; Soon H. Kim; Jong W. Kwon; Won B. Kim; Sh πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 English βš– 107 KB πŸ‘ 2 views

The subacute toxicities and toxicokinetics of a new erectogenic, DA-8159, were evaluated after single (at the 1st day) and 4-week (at the 28th day) oral administration of the drug, in doses of 0 (to serve as a control), 12.5, 50 and 200 mg/kg/day, to male and female dogs (n ΒΌ 3 for male and female d