𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Effects of enzyme inducers and inhibitors on the pharmacokinetics of intravenous DA-8159, a new erectogenic, in rats

✍ Scribed by Yu C. Kim; Hyun J. Shim; Joo H. Lee; Soon H. Kim; Jong W. Kwon; Won B. Kim; Myung G. Lee

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
135 KB
Volume
26
Category
Article
ISSN
0142-2782

No coin nor oath required. For personal study only.

πŸ“œ SIMILAR VOLUMES

Effects of omeprazole or cola beverage o
Effects of omeprazole or cola beverage on the pharmacokinetics of oral DA-8159, a new erectogenic, in rats
✍ Joo H. Lee; Soo K. Bae; Jong W. Kwon; Won B. Kim; Myung G. Lee πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 91 KB πŸ‘ 1 views

## Abstract The changes in pharmacokinetics of DA‐8159 by omeprazole with respect to inhibition of CYP3A1/2 in rats were evaluated. After oral administration of DA‐8159 at dose of 30 mg/kg to rats pretreated with oral omeprazole at 30 mg/kg for 1 week, the total area under the plasma concentration–

Interspecies pharmacokinetic scaling of
Interspecies pharmacokinetic scaling of DA-8159, a new erectogenic, in mice, rats, rabbits and dogs, and prediction of human pharmacokinetics
✍ Hyun J. Shim; Yu C. Kim; Joo H. Lee; Jong W. Kwon; Won B. Kim; Yoon G. Kim; So H πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 122 KB πŸ‘ 1 views

Time-averaged total body clearance (Cl) and apparent volume of distribution at steady state (V SS ) of DA-8159 after intravenous administration to mice (30 mg/kg), rats (30 mg/kg), rabbits (30 mg/kg) and dogs (3 mg/kg) were analysed as a function of species body weight (W) using the allometric equat