Effect of phenytoin on the pharmacokinet
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Barry J. Cusack; Dwaine A. Tesnohlidek; Vicki L. Loseke; Robert E. Vestal; Dean
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Article
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1988
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Springer
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English
β 541 KB
Doxorubicin is metabolized extensively to doxorubicinol by the ubiquitous aldoketoreductase enzymes. The extent of conversion to this alcohol metabolite is important since doxorubicinol may be the major contributor to cardiotoxicity. Aldoketoreductases are inhibited in vitro by phenytoin. The presen