Doxorubicin and doxorubicinol: intra-and inter-individual variations of pharmacokinetic parameters
✍ Scribed by Jeanne-Marie Jacquet; Françoise Bressolle; Marc Galtier; Magali Bourrier; Daniel Donadio; Jacques Jourdan; Jean-François Rossi
- Publisher
- Springer
- Year
- 1990
- Tongue
- English
- Weight
- 646 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0344-5704
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Doxorubicin is metabolized extensively to doxorubicinol by the ubiquitous aldoketoreductase enzymes. The extent of conversion to this alcohol metabolite is important since doxorubicinol may be the major contributor to cardiotoxicity. Aldoketoreductases are inhibited in vitro by phenytoin. The presen
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