𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Doxorubicin and doxorubicinol pharmacokinetics and tissue concentrations following bolus injection and continuous infusion of doxorubicin in the rabbit

✍ Scribed by Barry J. Cusack; Stephan P. Young; Joni Driskell; Richard D. Olson

Publisher
Springer
Year
1993
Tongue
English
Weight
724 KB
Volume
32
Category
Article
ISSN
0344-5704

No coin nor oath required. For personal study only.

πŸ“œ SIMILAR VOLUMES

Effect of phenytoin on the pharmacokinet
Effect of phenytoin on the pharmacokinetics of doxorubicin and doxorubicinol in the rabbit
✍ Barry J. Cusack; Dwaine A. Tesnohlidek; Vicki L. Loseke; Robert E. Vestal; Dean πŸ“‚ Article πŸ“… 1988 πŸ› Springer 🌐 English βš– 541 KB

Doxorubicin is metabolized extensively to doxorubicinol by the ubiquitous aldoketoreductase enzymes. The extent of conversion to this alcohol metabolite is important since doxorubicinol may be the major contributor to cardiotoxicity. Aldoketoreductases are inhibited in vitro by phenytoin. The presen

The influence of ranitidine on the pharm
The influence of ranitidine on the pharmacokinetics and toxicity of doxorubicin in rabbits
✍ N. Lindsay Harris; Dean E. Brenner; Lowell B. Anthony; Jerry C. Collins; Susan H πŸ“‚ Article πŸ“… 1988 πŸ› Springer 🌐 English βš– 596 KB

The influence of ranitidine on the pharmacokinetics and toxicity of doxorubicin was studied in six female New Zealand white rabbits. Plasma pharmacokinetic data were first obtained from rabbits given 3 mg/kg doxorubicin. After 1 month, the same rabbits were treated with ranitidine, 2.5 mg/kg or 25 m