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Pharmacokinetics of diphemanil methylsulphate in neonates and in premature infants

✍ Scribed by A. Pariente-Khayat, A. M. Vidal, G. Cheron…

Book ID
120759475
Publisher
Springer
Year
1996
Tongue
English
Weight
184 KB
Volume
50
Category
Article
ISSN
0031-6970

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The pharmacokinetics of diphemanil methylsulphate was evaluated after oral administration of a single 3 mg.kg-1 dose to 5 infants being treated for symptomatic bradycardia. The mean pharmacokinetic parameters of oral diphemanil methylsulphate in infants were similar to those in adults. The mean half

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The pharmacokinetic parameters of oral diphemanil methylsulphate have been evaluated in six healthy male volunteers. Absorption of the drug was slow (tmax = 2 to 4 h), the mean half-life was 8.35 h, and the amount of the drug recovered in urine within 48 h ranged from 0.6 to 7.4% of the administered

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