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Pharmacokinetics of diphemanil methylsulphate in healthy subjects

✍ Scribed by A. M. Vidal; E. Rey; G. Pons; J. Y. Pello; Ph. d'Athis; G. Olive

Publisher
Springer
Year
1992
Tongue
English
Weight
259 KB
Volume
42
Category
Article
ISSN
0031-6970

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✦ Synopsis

The pharmacokinetic parameters of oral diphemanil methylsulphate have been evaluated in six healthy male volunteers. Absorption of the drug was slow (tmax = 2 to 4 h), the mean half-life was 8.35 h, and the amount of the drug recovered in urine within 48 h ranged from 0.6 to 7.4% of the administered dose. The results suggest low bioavailability, assuming that the drug is poorly metabolized.

πŸ“œ SIMILAR VOLUMES

Pharmacokinetics of diphemanil methylsul
Pharmacokinetics of diphemanil methylsulphate in infants
✍ A. M. Vidal; G. ChΓ©ron; E. Rey; G. Pons; P. d'Athis; G. Olive πŸ“‚ Article πŸ“… 1993 πŸ› Springer 🌐 English βš– 209 KB

The pharmacokinetics of diphemanil methylsulphate was evaluated after oral administration of a single 3 mg.kg-1 dose to 5 infants being treated for symptomatic bradycardia. The mean pharmacokinetic parameters of oral diphemanil methylsulphate in infants were similar to those in adults. The mean half