Pharmacokinetics of fexofenadine enantiomers in healthy subjects
β Scribed by Masatomo Miura; Tsukasa Uno; Tomonori Tateishi; Toshio Suzuki
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 99 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0899-0042
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Nefopam (NEF) is a potent analgesic compound administered as a racemic mixture. Previous in vitro and in vivo studies with nefopam enantiomers have shown that (+)nefopam [(+)NEF] is substantially more potent than (-)nefopam [(-)NEF]. Differences between enantiomers have also been suggested in metabo
The objective of the current investigation was to describe the pharmacokinetics and absolute oral bioavailability of epristeride. Twelve healthy male subjects (mean (SD) age, 27 (6.2) years) received a single oral dose of 5mg and an intravenous infusion of 4.5 mg over 30 min in a crossover fashion.
The pharmacokinetics and dose proportionality of fexofenadine, a new non-sedating antihistamine, and its enantiomers were characterized after single and multiple-dose administration of its hydrochloride salt. A total of 24 healthy male volunteers (31 98 years) received oral doses of 20, 60, 120 and