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Pharmacokinetics of diphemanil methylsulphate in infants

✍ Scribed by A. M. Vidal; G. Chéron; E. Rey; G. Pons; P. d'Athis; G. Olive

Publisher
Springer
Year
1993
Tongue
English
Weight
209 KB
Volume
45
Category
Article
ISSN
0031-6970

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✦ Synopsis

The pharmacokinetics of diphemanil methylsulphate was evaluated after oral administration of a single 3 mg.kg-1 dose to 5 infants being treated for symptomatic bradycardia. The mean pharmacokinetic parameters of oral diphemanil methylsulphate in infants were similar to those in adults. The mean half-life was 8.6 h. This would allow administration three times a day in infants instead of four to six times a day, as currently prescribed. The mean residence time decreases significantly with age (Spearman's r' = -1), and there is a trend for the half-life to decrease with age (r' = -0.9; NS), suggesting an influence of maturation on its elimination.

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