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Pharmacokinetics of cytosine arabinoside in cerebrospinal fluid and of its metabolite in leukemic cells

✍ Scribed by Békássy, Albert N. ;Liliemark, Jan ;Garwicz, Stanislaw ;Wiebe, Thomas ;Gulliksson, Hans ;Peterson, Curt

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
640 KB
Volume
18
Category
Article
ISSN
0098-1532

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✦ Synopsis

Abstract

Concentrations of ara‐CTP in leukemic cells isolated from CSF and of ara‐C in lumbar CSF were measured following intraventricular ara‐C administration in two girls with refractory meningeal leukemia. CSF samples were collected with a permanent intrathecal‐lumbar catheter. In contrast to the comparatively short retention of ara‐C in the CSF (t1/2 1.8 to 2.9 hours), there was a high accumulation and an extremely long retention of ara‐CTP in the leukemic cells (t1/2 8.1 to 36 hours). The patients included in this study had an ara‐C‐resistant disease. No obvious relationship was seen between concentrations of ara‐C in the CSF and of ara‐CTP in the leukemic cells. Similar studies were performed after simultaneous intraventricular administration of hydrocortison and ara‐C. Hydrocortison did not increase ara‐CTP retention in the leukemic cells, nor did it effect CSF pleocytosis.

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