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Pharmacokinetics of vinpocetine and its metabolite, apovincaminic acid, in plasma and cerebrospinal fluid after intravenous infusion

✍ Scribed by Margarita Polgár; László Vereczkey; István Nyáry

Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
641 KB
Volume
3
Category
Article
ISSN
0731-7085

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✦ Synopsis

The pharmacokinetics of vinpocetine (ethyl apovincaminate, Cavinton) and its metabolite, apovincaminic acid, was studied in patients with cerebrovascular disorders. Vinpocetine (1 mg/kg) was infused intravenously over 25 min. The elimination half-life of the parent drug in plasma was 4.7k2.13 h. Total clearance of vinpocetine was 0.79kO.l 1 h-' kg-'. The presence of vinpocetine in cerebrospinal fluid shows that the drug is able to pass through the blood-brain barrier and reach the central nervous system which is a possible site of action. The maximum increase of cerebral blood flow (25%) was measured at 32 min after the start of the infusion.

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