Pharmacokinetics of cisplatin and relation to nephrotoxicity in paediatric patients
β Scribed by Bernhard Erdlenbruch; Marit Nier; Wolfgang Kern; Wolfgang Hiddemann; Arnulf Pekrun; Max Lakomek
- Publisher
- Springer
- Year
- 2001
- Tongue
- English
- Weight
- 177 KB
- Volume
- 57
- Category
- Article
- ISSN
- 0031-6970
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π SIMILAR VOLUMES
## Abstract The incidence of nephrotoxicity has been studied in 175 patients who received either gentamicin or tobramycin. All patients received individualized dosing regimens of the drugs based on pharmacokinetic parameters measured after the initial dose. Subsequent doses were calculated from the
Background. Treatment with high-dose cisdiammine-dichloroplatinum (11) (cisplatin, cDDP) often is associated with late complications, predominated by peripheral neuropathy. Pt deposition in different tissues may play a key role in the induction of many of these effects. Main topics of interest inclu