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Noninvasive follow-up of platinum pharmacokinetics in the skin of patients on cisplatin chemotherapy

✍ Scribed by Raphael Gorodetsky; Xiaode Mou; Akiva Vexler; Bella Kaufman; Raphael Catane; Elia Loewenthal

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
774 KB
Volume
72
Category
Article
ISSN
0008-543X

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✦ Synopsis

Background. Treatment with high-dose cisdiammine-dichloroplatinum (11) (cisplatin, cDDP) often is associated with late complications, predominated by peripheral neuropathy. Pt deposition in different tissues may play a key role in the induction of many of these effects. Main topics of interest include the relationship between cDDP doses given during treatment and the longterm pharmacokinetics of the drug complexes in normal tissues and blood. Noninvasive examination of Pt in tissues during and after cDDP treatment are needed to clarify these points.

Methods. A novel, high-sensitivity diagnostic x-ray spectrometry (DXS) method was used for the fast, noninvasive analysis of Pt in external tissues of patients with cancer treated with courses of cDDP. The Pt in a small skin area was excited by a monochromatic soft x-ray beam (14.6 KeV) and the spectral L lines emitted from the tissue were detected. A limit of detection below 1 pg/g wet weight was reached. The pharmacokinetics of Pt in blood was investigated in parallel with the use of highsensitivity, flameless atomic absorption spectrometry (AAS).

Results. Follow-up of Pt concentrations in the skin of patients with cancer by DXS before cDDP treatment, during treatment, and up to 4 months after its completion, showed prolonged Pt deposition that corresponded to the net cumulative doses of the drug. Pt clearance from the skin fitted a monoexponential curve with a half-life of ~~

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