## Abstract In order to determine the potential pharmacokinetic drug interaction between ranitidine and diltiazem (DTZ), each of ten male beagle dogs, age 2Β·7β4Β·0 years, weight 13β16 kg, received a single oral dose of sustained release DTZ with and without previous multiple oral doses of ranitidine
Pharmacokinetics of bretylium in dogs and the effect of hemoperfusion on elimination
β Scribed by B. L. Kamath; T. P. Gibson; Z. M. Look; C. M. McEntegart; E. B. Comrie; A. Yacobi
- Publisher
- John Wiley and Sons
- Year
- 1982
- Tongue
- English
- Weight
- 403 KB
- Volume
- 71
- Category
- Article
- ISSN
- 0022-3549
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## Abstract The pharmacokinetics of HIβ6 were studied following intravenous administration to beagle dogs (__n__ = 7). The bioavailability of two different strength intramuscularly administered doses was also determined in the same animals. After a 20 mg kg^β1^ intravenous dose, the mean (Β±S.D.) in