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Pharmacokinetics of azithromycin after single oral dosing of experimental animals

✍ Scribed by D. Davila; Lidija Kolačny-babić; F. Plavšić

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
421 KB
Volume
12
Category
Article
ISSN
0142-2782

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Azithromycin, a macrolide antibiotic with an enhanced antimicrobial spectrum, was found to have a longer half‐life than erythromycin, with marked tissue penetration. The pharmacokinetics of azithromycin after oral administration were compared with those of erythromycin in rats (200 mg kg^−1^) and rabbits (80 mg kg^−1^). Concentrations of azithromycin in liver, lung, kidney, ileum, and brain were higher than serum concentrations. The slow decline in tissue concentrations was evident from the biphasic elimination profile. Thus, advantageous pharmacokinetic properties and the broader antimicrobial spectrum of azithromycin relative to erythromycin appear to further support its therapeutic potential.

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