𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Dose dependent pharmacokinetics of N-ACETYLCYSTEINE AFTER ORAL DOSING TO MAN

✍ Scribed by Lars Borgström; Bertil Kågedal

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
294 KB
Volume
11
Category
Article
ISSN
0142-2782

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The pharmacokinetics after oral administration of 200, 600 or 1200 mg of N‐acetylcysteine (NAC) were studied in 10 healthy subjects. Normalized maximal plasma concentration was significantly higher after a 600 mg dose than after a 200 mg dose. Bioavailability of NAC significantly increased with increasing dose. Time for maximal plasma concentration also increased with increasing dose. The observations can be explained by a capacity‐limited presystemic elimination of NAC. In an extension of the study, 600 mg of NAC was given twice a day for 5 days and the plasma concentrations were followed after the morning dose on day 6. No differences in the pharmacokinetic parameters were observed in comparison with the single 600 mg dose. This indicates that the beneficial clinical effects observed after repeated dosing can not be ascribed to an accumulation of NAC in plasma.

📜 SIMILAR VOLUMES

DOSE DEPENDENT PHARMACOKINETICS OF NAPRO
DOSE DEPENDENT PHARMACOKINETICS OF NAPROXEN IN MAN
✍ Sarfaraz K. Niazi; S. Mahmood Alam; S. I. Ahmad 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 389 KB 👁 1 views

The pharmacokinetics of one of the most widely used non-steroidal antiinflammatory drugs, naproxen, were studied in 28 healthy human volunteers at the two most commonly used dose levels, viz., 250 mg and 500 mg, in a cross-over design. The plasma levels of naproxen were analysed by a modified high-p

Clinical pharmacokinetics of procaterol:
Clinical pharmacokinetics of procaterol: Dose proportionality after administration of single oral doses
✍ Dr Michael A. Eldon; Debbie S. Blake; Michael J. Coon; Gerald D. Nordblom; Allen 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 328 KB 👁 2 views

Procaterol is a potent, orally active &-agonist bronchodilator useful in the treatment of reversible bronchospastic disease. It is effective when administered as single or multiple (Q8H) 50 and 75pg doses. As part of the clinical development of procaterol, the pharmacokinetics and dose proportionali

Pharmacokinetics of deramciclane in dogs
Pharmacokinetics of deramciclane in dogs after single oral and intravenous dosing and multiple oral dosing
✍ Harri Kanerva; Hannele Huuskonen; Anneli Alhonen-Raatesalmi; Timo Nevalainen; Ar 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 204 KB 👁 2 views

The pharmacokinetics of a new serotonin 5-HT 2 antagonist, deramciclane, was studied. Single oral doses of 1, 3, 6 and 10 mg kg -1 and intravenous doses of 1, 3 and 6 mg kg -1 were administered in beagle dogs. Moreover, the steady state pharmacokinetics of 1, 3 and 6 mg kg -1 doses were studied. Der

Pharmacokinetics of furosemide after thr
Pharmacokinetics of furosemide after three different single oral doses
✍ Elaine S. Waller; Joseph W. Massarella; Motria Sharanevych Tomkiw; Robert V. Smi 📂 Article 📅 1985 🏛 John Wiley and Sons 🌐 English ⚖ 396 KB 👁 2 views

Furosemide solution was orally administered to 21 healthy adult males to determine dose proportionality over the dose range used and the reproducibility of disposition following a repeated dose. Furosemide solution was given in doses of 20,40, and 80mg, with the 40 mg dose repeated once. Blood was c

Pharmacokinetics of azithromycin after s
Pharmacokinetics of azithromycin after single oral dosing of experimental animals
✍ D. Davila; Lidija Kolačny-babić; F. Plavšić 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 421 KB 👁 2 views

## Abstract Azithromycin, a macrolide antibiotic with an enhanced antimicrobial spectrum, was found to have a longer half‐life than erythromycin, with marked tissue penetration. The pharmacokinetics of azithromycin after oral administration were compared with those of erythromycin in rats (200 mg k