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Pharmacokinetics of atenolol enantiomers in humans and rats

โœ Scribed by Reza Mehvar; Mary E. Gross; Robert N. Kreamer

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
573 KB
Volume
79
Category
Article
ISSN
0022-3549

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Pharmacokinetics of acebutolol enantiome
Pharmacokinetics of acebutolol enantiomers in humans
โœ Micheline Piquette-Miller; Robert T. Foster; Chulani T. Kappagoda; Fakhreddin Ja ๐Ÿ“‚ Article ๐Ÿ“… 1991 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 460 KB

The chiral beta-blocker acebutolol (AC) is marketed as a racemic mixture. Both AC and its major metabolite, diacetotol (DC), are chiral, the S-enantiomer possessing beta-blocking activity. The pharmacokinetics of AC and DC enantiomers was determined in 12 healthy subjects following oral administrati