Flurbiprofen is a chiral 2-arylpropionate used clinically as a racemate. Previously a significant pharmacokinetic interaction between the enantiomers of flurbiprofen has been reported in both rats and humans. The possible mechanism for this interaction was believed to involve competitive protein bin
Stereoselective pharmacokinetics of flurbiprofen in humans and rats
β Scribed by Fakhreddin Jamali; Brian W. Berry; Morteza R. Tehrani; Anthony S. Russell
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 430 KB
- Volume
- 77
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Stereoselectivity of the pharmacokinetics of the nonsteroidal antiinflammatory drug flobufen, 4-(2Π,4Π-difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoic acid, was studied in male Wistar rats after intravenous administration. Pharmacokinetic parameters and chiral inversion of flobufen enantiomers were st
The route of administration of the NSAID, flurbiprofen (sq vs. PO) resulted in positive and negative results respectively with regard to enhanced cancellous and cortical bone accumulation in the immature rat. This pharmacokinetic study was an effort to understand the pharmacodynamic difference betwe