Validation of subcutaneous microdialysis sampling for pharmacokinetic studies of flurbiprofen in the rat
✍ Scribed by François-xavier Mathy; Véronique Preat; Roger K. Verbeeck
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 181 KB
- Volume
- 90
- Category
- Article
- ISSN
- 0022-3549
- DOI
- 10.1002/jps.1139
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📜 SIMILAR VOLUMES
Flurbiprofen is a chiral 2-arylpropionate used clinically as a racemate. Previously a significant pharmacokinetic interaction between the enantiomers of flurbiprofen has been reported in both rats and humans. The possible mechanism for this interaction was believed to involve competitive protein bin
The route of administration of the NSAID, flurbiprofen (sq vs. PO) resulted in positive and negative results respectively with regard to enhanced cancellous and cortical bone accumulation in the immature rat. This pharmacokinetic study was an effort to understand the pharmacodynamic difference betwe