Pharmacokinetics and pharmacodynamic effects of 5-fluorouracil given as a one-hour intravenous infusion
β Scribed by Jean L. Grem; Mary Quinn; Abdel Ismail; Chris H. Takimoto; Richard Lush; David J. Liewehr; Seth M. Steinberg; Frank M. Balis; Alice P. Chen; Brian P. Monahan; Nancy Harold; William Corse; Janet Pang; Robert F. Murphy; Carmen J. Allegra; Michael J. Hamilton
- Publisher
- Springer
- Year
- 2001
- Tongue
- English
- Weight
- 243 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0344-5704
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## Abstract To determine the maximum tolerated dose of 5βfluorouracil administered as a 120βhour continuous intravenous infusion to pediatric patients, we performed a phase I study using a starting dosage of 900 mg/m^2^/day. The maximum tolerated dosage (MTD) was 1,100 mg/m^2^/day. At this dosage l