Effect of intravenous infusion time on the pharmacokinetics and pharmacodynamics of the same total dose of torasemide in rabbits
โ Scribed by Yu C. Kim; Myung G. Lee; Seong-Hee Ko; So H. Kim
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 110 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0142-2782
- DOI
- 10.1002/bdd.401
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## Abstract The interaction between indomethacin (IND) and methotrexate (MTX) was investigated in rabbits. The study was designed so as to evaluate the effect of IND (1 mg h^โ1^) during a continuous MTX infusion (1ยท2 mg kg^โ1^) over 240 min. IND was injected i.v. at hourly intervals after a steady