Effect of atorvastatin on the intravenous and oral pharmacokinetics of verapamil in rats
โ Scribed by Dong-Hyun Choi; Kyong-Sig Chang; Soon-Pyo Hong; Jun-Shik Choi; Hyo-Kyung Han
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 106 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0142-2782
- DOI
- 10.1002/bdd.582
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The pharmacokinetics of the anticholinergic drug ethopropazine (ET) have been studied in the rat after intravenous (i.v.) and oral administration. After i.v. doses of 5 and 10 mg/kg ET HCl, mean +/- S.D. plasma AUC were 9836 +/- 2129 (n = 4 rats) and 13096 +/- 4186 ng h/mL (n = 5 rats), respectively
## Abstract It was reported that the area under the plasma concentrationโtime curve from time zero to time infinity (AUC) of parathion was significantly smaller, and the timeโaveraged total body clearance (Cl) of parathion was significantly faster after intravenous administration of parathion to ra