Pharmacokinetics and metabolism of idebenone in healthy male subjects
✍ Scribed by Michael Bodmer; Pierre Vankan; Manfred Dreier; Klaus W. Kutz; Jürgen Drewe
- Publisher
- Springer
- Year
- 2009
- Tongue
- English
- Weight
- 202 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0031-6970
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The objective of the current investigation was to describe the pharmacokinetics and absolute oral bioavailability of epristeride. Twelve healthy male subjects (mean (SD) age, 27 (6.2) years) received a single oral dose of 5mg and an intravenous infusion of 4.5 mg over 30 min in a crossover fashion.
## Abstract The pharmacokinetics of 2 mg ketotifen from four different oral dosage forms were examined in two randomized, balanced cross‐over studies. Forty healthy male subjects participated. Each of 20 subjects received two capsule formulations and each of the other 20 subjects received two syrup