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Pharmacokinetics and metabolism in early drug discovery

โœ Scribed by Dennis A Smith; Han van de Waterbeemd

Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
663 KB
Volume
3
Category
Article
ISSN
1367-5931

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โœฆ Synopsis

The need for high-throughput approaches in absorption, distribution, metabolism and excretion studies is driven by the impact of high-speed chemistry and pharmacological screening. Perhaps an even greater impact is that these studies will, in the future, provide large data sets that can be used to predict biological events related to absorption, bioavailability and metabolism of drugs. Through linking of in silica and in vitro methods, considerable progress has recently been made towards this future perspective. Despite this progress, these approaches do not yet replace in viva methods.

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