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Pharmacokinetics and bioavailability of methocarbamol in rats

✍ Scribed by R. Obach; J. Pruñonosa; A. Menargues; M. Nomen; J. Vallès

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
467 KB
Volume
9
Category
Article
ISSN
0142-2782

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✦ Synopsis

In a pharmacokinetic study, 15, 30, 60, and 150 mg kg-' intravenous and oral doses of methocarbamol were administered to rats. Differences observed in plasma clearance values, i.e. 0~0203,0~0156,0~0123, and 0-0085 1 kg-' min-' for 15,30,60, and 150 mg kg-', respectively, suggested a dosedependent pharmacokinetic behaviour of the drug. Elimination according to a biocompartmental open model and Michaelis-Menten kinetics fits the plasma level data. Estimated Km and V,,, values were 38-49 k 3-71 mg I-' and 1.24 f 0.06 mg 1-' min-', respectively. After oral administration of 15,30, and 60 mg kg-' the peak plasma levels were reached earlier. The tmax values were 6, 6, and 10 min, respectively. After 150 mg kg-' oral doses, peak plasma levels were reached later (tmax = 150 min). Estimated bioavailability ranged between 77 and 112 per cent.

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