✦ LIBER ✦

Bioavailability of cyanamide in fasted and unfasted rats

✍ Scribed by R. Obach; C. Valenti; J. Valles; J. M. Valles; J. Domenech

Publisher: John Wiley and Sons
Year: 1986
Tongue: English
Weight: 353 KB
Volume: 7
Category: Article
ISSN: 0142-2782
DOI: 10.1002/bdd.2510070308

No coin nor oath required. For personal study only.

✦ Synopsis

The pharmacokinetics of cyanamide after 35 mg kg-' intravenous and oral administration to fasted and unfasted rats have been investigated. The plasma level are fitted well by a two-compartment open model. The half-life ( t l p) of c anamide in the rat was 1 hour and the plasma clearance (Cl,) was 0.02 (1 kg-5 min-? Food does not appear to modify the absolute bioavailability of cyanamide ( F = 9 3 . 3 per cent fasted, F = 85.5 per cent unfasted), although it does retard drug absorption.

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