The pharmacokinetics of ketamine in analgesic doses after intravenous, intramuscular, and oral administration was investigated in healthy volunteers. Plasma ketamine concentration-time curves were fitted by a two-compartment open model with a terminal half-life of 186 min. Absorption after intramusc
Pharmacokinetics and bioavailability of ciramadol, a new analgesic
β Scribed by Ann Locniskar; Kenneth C. Lasseter; George R. Freeland; Soong T. Chiang; Dr. David J. Greenblatt
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- English
- Weight
- 280 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0272-4391
No coin nor oath required. For personal study only.
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Eleven healthy volunteers completed a study to compare the relative bioavailability to orally administered ciramadol in a fasting versus postprandial state. A single oral dose of 30mg of ciramadol was administered on two separate occasions, 2 weeks apart, in a randomized crossover study. A mono-or b
The bioavailability of a new, slow-release potassium chloride product consisting of coated beads in a hard gelatin capsule was compared with the bioavailahility of two marketed products, an elixir and a slowrelease tablet, by determining the urinary excretion of potassium. Twelve healthy male volunt
In a pharmacokinetic study, 15, 30, 60, and 150 mg kg-' intravenous and oral doses of methocarbamol were administered to rats. Differences observed in plasma clearance values, i.e. 0~0203,0~0156,0~0123, and 0-0085 1 kg-' min-' for 15,30,60, and 150 mg kg-', respectively, suggested a dosedependent ph