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Pharmacokinetics and Antitumor Effects of the Drug Containing TNF-α in Nanoparticles

✍ Scribed by S. G. Gamaley; A. V. Bateneva; G. M. Sysoeva; E. D. Danilenko; L. R. Lebedev; V. I. Masycheva


Publisher
Springer US
Year
2010
Tongue
English
Weight
153 KB
Volume
149
Category
Article
ISSN
0007-4888

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## Abstract L19‐IL2 and L19TNFα are fusion proteins composed of L19(scFv), specific for the angiogenesis‐associated ED‐B containing fibronectin isoform and IL‐2 or TNFα. Because of the tumor targeting properties of L19, IL‐2 and TNFα concentrate at therapeutic doses at the tumor vascular level. To