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Pharmacokinetics and anti-emetic efficacy of BRL43694, a new selective 5HT-3 antagonist

✍ Scribed by Cassidy, J; Raina, V; Lewis, C; Adams, L; Soukop, M; Rapeport, WG; Zussman, BD; Rankin, EM; Kaye, SB

Book ID
109836028
Publisher
Nature Publishing Group
Year
1988
Tongue
English
Weight
608 KB
Volume
58
Category
Article
ISSN
0007-0920

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A phase I study of a new 5HT3-receptor a
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✍ Geoffrey Falkson; Adriaan J. Zyl πŸ“‚ Article πŸ“… 1989 πŸ› Springer 🌐 English βš– 370 KB

In a phase I study of BRL43694A, a 5HT3-receptor antagonist, a single dose of 40 micrograms/kg was given to 24 patients. All patients received cytostatic treatment expected to cause nausea and vomiting. During the first 24 h, 12 patients were completely protected from nausea and vomiting, 4 experien