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The broad-spectrum anti-emetic activity of AS-8112, a novel dopamine D2, D3 and 5-HT3 receptors antagonist

✍ Scribed by Takashi Yoshikawa; Naoyuki Yoshida; Makoto Oka


Book ID
110005702
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
208 KB
Volume
133
Category
Article
ISSN
0007-1188

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Agonist and antagonist actions of yohimb
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Herein, we evaluate the interaction of the ␣ 2 -AR antagonist, yohimbine, as compared to fluparoxan, at multiple monoaminergic receptors and examine their roles in the modulation of adrenergic, dopaminergic and serotonergic transmission in freelymoving rats. Yohimbine displays marked affinity at hum