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A pharmacokinetic study of granisetron (BRL 43694A), a selective 5-HT3receptor antagonist: correlation with anti-emetic response

โœ Scribed by J. Carmichael; B. M. J. Cantwell; C. M. Edwards; B. D. Zussman; S. Thompson; W. G. Rapeport; A. L. Harris


Book ID
104684445
Publisher
Springer
Year
1989
Tongue
English
Weight
479 KB
Volume
24
Category
Article
ISSN
0344-5704

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A phase I study of a new 5HT3-receptor a
โœ Geoffrey Falkson; Adriaan J. Zyl ๐Ÿ“‚ Article ๐Ÿ“… 1989 ๐Ÿ› Springer ๐ŸŒ English โš– 370 KB

In a phase I study of BRL43694A, a 5HT3-receptor antagonist, a single dose of 40 micrograms/kg was given to 24 patients. All patients received cytostatic treatment expected to cause nausea and vomiting. During the first 24 h, 12 patients were completely protected from nausea and vomiting, 4 experien