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Pharmacokinetically guided dose escalation in phase I clinical trials. Commentary and proposed guidelines


Book ID
122690499
Publisher
Elsevier Science
Year
1987
Weight
563 KB
Volume
23
Category
Article
ISSN
0277-5379

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We describe an adaptive dose escalation scheme for use in cancer phase I clinical trials. The method is fully adaptive, makes use of all the information available at the time of each dose assignment, and directly addresses the ethical need to control the probability of overdosing. It is designed to