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Dose escalation with overdose control using a quasi-continuous toxicity score in cancer Phase I clinical trials

✍ Scribed by Zhengjia Chen; Mourad Tighiouart; Jeanne Kowalski


Book ID
118428073
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
278 KB
Volume
33
Category
Article
ISSN
1551-7144

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We describe an adaptive dose escalation scheme for use in cancer phase I clinical trials. The method is fully adaptive, makes use of all the information available at the time of each dose assignment, and directly addresses the ethical need to control the probability of overdosing. It is designed to