Cancer phase I clinical trials: efficien
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James Babb; AndrΓ© Rogatko; Shelemyahu Zacks
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Article
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1998
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John Wiley and Sons
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English
β 172 KB
π 1 views
We describe an adaptive dose escalation scheme for use in cancer phase I clinical trials. The method is fully adaptive, makes use of all the information available at the time of each dose assignment, and directly addresses the ethical need to control the probability of overdosing. It is designed to