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Dose Escalation Methods in Phase I Cancer Clinical Trials

✍ Scribed by Le Tourneau, C.; Lee, J. J.; Siu, L. L.

Book ID
124050251
Publisher
Oxford University Press
Year
2009
Tongue
English
Weight
232 KB
Volume
101
Category
Article
ISSN
0027-8874

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We describe an adaptive dose escalation scheme for use in cancer phase I clinical trials. The method is fully adaptive, makes use of all the information available at the time of each dose assignment, and directly addresses the ethical need to control the probability of overdosing. It is designed to