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Pharmacokinetic aspects of palinavir, an HIV protease inhibitor, in Sprague–Dawley rats

✍ Scribed by Francine Liard; Jorge Jaramillo; William L. Paris; Christiane Yoakim


Book ID
109388963
Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
68 KB
Volume
87
Category
Article
ISSN
0022-3549

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## Abstract The pharmacokinetics of a series of novel cyclic, non‐peptide inhibitors of HIV protease were studied in rats or dogs after intravenous and oral administration. Six symmetrically substituted cyclic urea compounds (XK234, XM311, XM320, XM321, XM323, and XM412), which effectively inhibite